Anti-Wee1 Ser123 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Toimittaja: Bioss
BS-5218R-A680
BOSSBS-5218R-A680EA 921 EUR
BOSSBS-5218R-A680
Anti-Wee1 Ser123 Rabbit Polyclonal Antibody (Alexa Fluor® 680)
Vasta-aineet
Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. AMore Product Information
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