1. Koti
  2. ABT-491 hydrochloride
  3. ABT-491 hydrochloride ≥98% (by HPLC), Calbiochem®, Sigma-Aldrich®
Tulosta…

ABT-491 hydrochloride ≥98% (by HPLC), Calbiochem®, Sigma-Aldrich®

Toimittaja: Merck Millipore Calbiochem


M-Clarity™ quality level = MQ100

511071-2
511071-2EA 227 EUR
511071-2
ABT-491 hydrochloride ≥98% (by HPLC), Calbiochem®, Sigma-Aldrich®
ABT-491 hydrochloride

The PAF Receptor Antagonist, ABT-491, also referenced under CAS 189689-94-9, controls the biological activity of PAF Receptor. This small molecule/inhibitor is primarily used for Membrane applications.


General description
An orally available ethynylindole compound that potently inhibits PAF (platelet-activating factor) binding to its receptor in a competitive manner in equilibrium binding studies (Ki = 0.6 or 3.8 nM, respectively, using intact human platelets or isolated rabbit platelet membrane; [PAF] = 0.6 nM), while a non-competitive inhibition is observed if the membrane-bound receptors are pre-incubated with the antagonist prior to the addition of PAF, presumably due to a slower antagonist dissociation rate. Shown to effectively antagonize PAF-induced platelet and neutrophil responses at submicromolar concentrations in vitro and exhibit in vivo efficacy in alleviating PAF-mediated inflammatory and pathological processes in various animals, including guinea pigs, mice, and rats, via either i.v. or p.o.. Reported to display high specificity toward PAF receptor as evaluated in binding assays employing a wide variety of receptors and ion channels.


Pakkaus: Packaged under inert gas

Kaava: C₂₈H₂₂FN₅O₂·xHCl
Storage Temperature: Jääkaappi
 MDL numero: MFCD00945301
CAS-numero: 189689-94-9

Order Now

TILAUS

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Lue lisää About VWR
Review & Compare Alternatives

We found alternative products that can save you up to  per item-unit.  To compare product details, select up to 3 alternatives below and click Compare Selected. To add items to your basket, enter a quantity and click Add to Basket.

How is savings calculated?
We multiply the savings per unit (in parenthesis) times the total units of the original product.

Original Product:
Tuotekuvaus Tuoteluettelon nro Availability Tuote Sinun hintasi Price Per lkm